基因名：
MLXIPL
产品别名：
CHREBP； MIO； MLX； MONDOB； WBSCR14； WS-bHLH； bHLHd14； MLXIPL； MLX interacting protein like； MLX interacting protein like； carbohydrate-responsive element-binding protein； Mlx interactor； WS basic-helix-loop-helix leucine zipper protein； Williams Beuren syndrome chromosome region 14； Williams-Beuren syndrome chromosome region 14 protein 1； Williams-Beuren syndrome chromosome region 14 protein 2； Williams-Beuren syndrome chromosome region 14 protein 3； carbohydrate response element binding protein； class D basic helix-loop-helix protein 14； williams-Beuren syndrome chromosomal region 14 protein； 糖类应答元件结合蛋白ChREBP；
背景信息：
ChREBP (Carbohydrate responsive element binding protein) is a transcription factor playing a critical role in the nutrient and hormonal regulation of genes encoding enzymes of glucose metabolism and lipogenesis pathways. It contains several domains including a nuclear localization signal (NLS) near the N-terminus, polyproline domains, a basic helix-loop-helix leucine zipper (b/HLH/Zip) and a leucine zipper like (zip-like) domain. ChREBP is ubiquitously detected in various tissues, with highest expression in liver, kidney and white and brown adipose tissue. Under basal conditions ChREBP is localized in the cytosol, translocating into the nucleus upon high glucose stimulation following its dephosphorylation of phospho-serine 196.
