基因名:
Mul1
产品别名:
CG1134; Dmel\CG1134; MUL1; mul1; Mul1; Mitochondrial E3 ubiquitin protein ligase 1; Mitochondrial E3 ubiquitin protein ligase 1; mitochondrial E3 ubiquitin protein ligase 1; CG1134-PA; CG1134-PB; Mul1-PA; Mul1-PB; mitochondrial E3 ubiquitin protein ligase 1 homologue; E3泛素连接酶; E3泛素连接酶MUL1;
背景信息:
E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.