基因名：
CD209
产品别名：
CDSIGN； CLEC4L； DC-SIGN； DC-SIGN1； hDC-SIGN； CD209； CD209 molecule； CD209 molecule； CD209 antigen； C-type lectin domain family 4 member L； HIV gpl20-binding protein； dendritic cell-specific ICAM-3-grabbing non-integrin 1； dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin； dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin； CD209分子(CD209)； 细胞间粘附分子非整合素蛋白3；
背景信息：
CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2, 4). DC-SIGN/CD209 binds to butyrophilin 2A1 and this interaction can be blocked by HIV pp120. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors.
