基因名:
KCNIP2
产品别名:
KCHIP2; KCNIP2; potassium voltage-gated channel interacting protein 2; potassium voltage-gated channel interacting protein 2; Kv channel-interacting protein 2; A-type potassium channel modulatory protein 2; Kv channel interacting protein 2; cardiac voltage-gated potassium channel modulatory subunit; potassium channel-interacting protein 2; 钾通道2;
背景信息:
The downstream regulatory element, DRE, acts as a location-dependent gene silencer. DREAM (for DRE-antagonist modulator) is a Ca2+-regulated transcriptional repressor that specifically binds to the DRE. DREAM regulates transcription of prodynorphin and c-Fos genes and shows 99% nucleotide homology to the Kv channel-interacting proteins (KChIPs). KChIP family members include KChIP1, which is expressed in brain, KChIP2, which is expressed in heart, brain, and lung, KChIP3 (also designated calsenilin), which is expressed in brain and testis and KChIP4.