基因名：
TBX21
产品别名：
IMD88； T-PET； T-bet； TBET； TBLYM； TBX21； T-box transcription factor 21； T-box transcription factor 21； T-box transcription factor TBX21； T-box 21； T-box expressed in T cells； T-box protein 21； T-cell-specific T-box transcription factor T-bet； transcription factor TBLYM； T-框蛋白21(TBX21)； T细胞介导的转录调节因子Tbx21；
背景信息：
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008].
