基因名：
CARD10
产品别名：
BIMP1； CARMA3； IMD89； CARD10； caspase recruitment domain family member 10； caspase recruitment domain family member 10； caspase recruitment domain-containing protein 10； Bcl10 binding protein and activator of NFKB； CARD-containing MAGUK 3 protein； CARD-containing MAGUK protein 3； carma 3； BCL10结合蛋白和激活核转录因子；
背景信息：
Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family, including the caspase recruitment domain (CARD) protein family with the exception of CARD9. The CARD domain consists of 6 or 7 antiparallel alpha helices. CARD family members participate in apoptosis signaling through highly specific protein-protein homophilic interactions. CARD 10 (also designated CARD-containing MAGUK protein 3 or Carma 3) interacts with BCL-10 to activate NFⅹB. CARD10 is expressed in a variety of adult and fetal tissues, including heart, kidney and liver, and in multiple cancer cell lines.
