基因名：
UBE2T
产品别名：
FANCT； HSPC150； PIG50； UBE2T； ubiquitin conjugating enzyme E2 T； ubiquitin conjugating enzyme E2 T； ubiquitin-conjugating enzyme E2 T； E2 ubiquitin-conjugating enzyme T； HSPC150 protein similar to ubiquitin-conjugating enzyme； cell proliferation-inducing gene 50 protein； ubiquitin carrier protein T； ubiquitin conjugating enzyme E2T； ubiquitin-conjugating enzyme E2T (putative)； ubiquitin-protein ligase T；
背景信息：
Ubiquitin-Conjugating Enzyme E2 T (UBE2T) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2T accepts the ATP-dependent ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, UBE2T is able to catalyze polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11'-, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination. UBE2T is an important factor of the Faconi anemia pathway of DNA damage repair and, upon self-inactivation, may negatively regulate the Faconi pathway.
