基因名：
C5AR2
产品别名：
C5L2； GPF77； GPR77； C5AR2； complement C5a receptor 2； complement C5a receptor 2； C5a anaphylatoxin chemotactic receptor 2； C5a anaphylatoxin chemotactic receptor C5L2； G protein-coupled receptor 77； G protein-coupled receptor C5L2； complement component 5a receptor 2； G蛋白偶联受体77； G蛋白偶联受体C5L2蛋白；
背景信息：
Anaphylatoxin, a chemotactic and inflammatory peptide, is a receptor for C5a anaphylatoxin chemotactic receptor (C5L2), also designated G protein-coupled receptor 77. C5L2 is an integral membrane protein that belongs to the Gprotein-coupled receptor 1 family. C5L2 weakly couples to Gi-mediated signaling pathways and is widely expressed in the hippocampus, hypothalamus, pons, frontal cortex and liver. It is coexpressed with the C5a receptor (C5AR) on polymorphonuclear neutrophils and may modulate the activity of C5AR. The function of the C5a receptors, particularly that of C5L2, is still unclear. Research suggests that C5L2 may be required for the in vitro release of high mobility group box 1 protein (HMGB1).
