基因名：
Fto
产品别名：
AW743446； mKIAA1752； Fto； fat mass and obesity associated； fat mass and obesity associated； alpha-ketoglutarate-dependent dioxygenase FTO； U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO； U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO； fat mass and obesity-associated protein； m6A(m)-demethylase FTO； mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO； mRNA N(6)-methyladenosine demethylase FTO； protein fatso； tRNA N1-methyl adenine demethylase FTO； 脂肪堆积和肥胖相关蛋白；
背景信息：
Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body fat accumulation.
Tissue specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially in hypothalamus and pituitary.
