重组泛素连接酶蛋白

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重组泛素连接酶蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

Recombinant RCHY1
Recombinant ring finger and CHY zinc finger domain containing 1 protein

基因名：

RCHY1

产品别名：

ARNIP； CHIMP； PIRH2； PRO1996； RNF199； ZCHY； ZNF363； RCHY1； ring finger and CHY zinc finger domain containing 1； ring finger and CHY zinc finger domain containing 1； RING finger and CHY zinc finger domain-containing protein 1； CH-rich interacting match with PLAG1； E3 ubiquitin-protein ligase Pirh2； RING finger protein 199； RING-type E3 ubiquitin transferase RCHY1； androgen-receptor N-terminal-interacting protein； p53-induced protein with a RING-H2 domain； ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase； zinc finger protein 363； zinc finger, CHY-type；泛素连接酶；

背景信息：

Pirh2 has p53-induced ubiquitin-protein ligase activity, promoting p53 degradation. The protein physically interacts with p53 and the resulting degradation of p53 renders Pirh2 an oncogenic protein as the loss of p53 function contributes to malignant tumor development. The gene encoding for the protein maps to chromosome 4q21.1 and transcription of this gene is regulated by p53. Pirh2 expression decreases the level of p53 and a decrease of endogenous Pirh2 expression ups p53 levels. Pirh2 is therefore considered, together with MDM2, to be acting as a negative regulator of p53 function.