基因名：
BACE2
产品别名：
AEPLC； ALP56； ASP1； ASP21； BAE2； CDA13； CEAP1； DRAP； BACE2； beta-secretase 2； beta-secretase 2； beta-secretase 2； 56 kDa aspartic-like protease； Down syndrome region aspartic protease； SLCO3A1/BACE2 fusion； aspartyl protease 1； beta-site APP-cleaving enzyme 2； beta-site amyloid beta A4 precursor protein-cleaving enzyme 2； memapsin-1； membrane-associated aspartic protease 1； theta-secretase； transmembrane aspartic proteinase Asp1； β-位淀粉样前体蛋白裂解酶2(BACE2)； β淀粉样前体蛋白裂解酶2；
背景信息：
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is the protein encoded by this gene. This gene localizes to the 'Down critical region' of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].
