基因名：
Sigirr
产品别名：
AI256711； TIR8； Sigirr； single immunoglobulin and toll-interleukin 1 receptor (TIR) domain； single immunoglobulin and toll-interleukin 1 receptor (TIR) domain； single Ig IL-1-related receptor； single Ig IL-1 receptor related protein； single Ig IL-1R-related molecule； single Ig IL-1R-related protein； single immunoglobulin domain-containing IL1R-related protein； toll/interleukin-1 receptor 8； IL-1相关Ig受体； 单Ig IL1相关受体(SIGIRR)；
背景信息：
Single Ig IL-1-related receptor SIGIRR, also designated single immunoglobulin domain-containing IL-1R-related protein or Toll/interleukin-1 receptor 8 (TIR8), is a member of the interleukin-1 receptor family. SIGIRR acts as a negative regulator of the IL-1R and Toll-like receptor signaling pathways and reduces the recruitment of certain components to the TLR4 receptor. Subsequently, SIGIRR confers resistance to P. aeruginosa corneal infection. SIGIRR can form complexes with IL-1R1, MYD-88, IRAK-1 and TRAF-6 upon IL-1 stimulation and TLR4 after LPS stimulation. It is a single-pass type III membrane protein that is mainly expressed in kidney, lung and gut.
