基因名：
RIGI
产品别名：
DDX58； RIG-I； RIG1； RLR-1； SGMRT2； RIGI； RNA sensor RIG-I； RNA sensor RIG-I； antiviral innate immune response receptor RIG-I； ATP-dependent RNA helicase DDX58； DEAD (Asp-Glu-Ala-Asp) box polypeptide 58； DEAD box protein 58； DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide； DExD/H-box helicase 58； RNA helicase RIG-I； probable ATP-dependent RNA helicase DDX58； retinoic acid-inducible gene 1 protein； retinoic acid-inducible gene I protein； 磷酸化DDX58；
背景信息：
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
