基因名：
TARDBP
产品别名：
ALS10； TDP-43； TARDBP； TAR DNA binding protein； TAR DNA binding protein； TAR DNA-binding protein 43； TAR DNA-binding protein-43； 43kDa Tar DNA结合蛋白(TDP43)； Tar DNA结合蛋白43/TDP-43；
背景信息：
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]
