基因名：
CRTC1
产品别名：
MAML2； MECT1； Mam-2； TORC-1； TORC1； WAMTP1； CRTC1； CREB regulated transcription coactivator 1； CREB regulated transcription coactivator 1； CREB-regulated transcription coactivator 1； Mastermind-like protein 2； mucoepidermoid carcinoma translocated protein 1； transducer of regulated cAMP response element-binding protein (CREB) 1； CREB调控转录辅激活因子1(CRTC1)； 环腺苷酸应答元件结合蛋白转录共激活因子TORC1； 磷酸化环腺苷酸应答元件结合蛋白转录共激活因子；
背景信息：
which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.
