基因名：
ARHGEF18
产品别名：
P114-RhoGEF； RP78； SA-RhoGEF； p114RhoGEF； ARHGEF18； Rho/Rac guanine nucleotide exchange factor 18； Rho/Rac guanine nucleotide exchange factor 18； rho guanine nucleotide exchange factor 18； 114 kDa Rho-specific guanine nucleotide exchange factor； Rho-specific guanine nucleotide exchange factor p114； Rho/Rac guanine nucleotide exchange factor (GEF) 18； septin-associated RhoGEF； G蛋白偶联受体ARHGEF18；
背景信息：
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
