基因名：
Ncf1
产品别名：
NCF-47K； NOXO2； Ncf-1； p47-phox； p47； p47phox； Ncf1； neutrophil cytosolic factor 1； neutrophil cytosolic factor 1； neutrophil cytosol factor 1； 47 kDa neutrophil oxidase factor； NADPH oxidase subunit (47 kD)； NADPH oxidase subunit (47kDa)； neutrophil NADPH oxidase factor 1； NADPH氧化酶活化蛋白p47； 嗜中性粒细胞胞浆因子1； 嗜中性粒细胞胞浆因子1(NCF1)； 磷酸化嗜中性粒细胞胞浆因子1；
背景信息：
Neutrophil cytosol factor 1( NCF1) is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. This oxidase is characterized as a multicomponent enzyme which is activated to produce superoxide anion. NCF2, NCF1, and a membrane bound cytochrome b558 are required for the activation of the latent NADPH oxidase. The human NCF1 gene encodes a 390 amino acids protein without a signal peptide. The NCF1 gene interacts with other subunits of nicotinamide adenine dinucleotide phosphate-oxidase (NADPH) and plays an important role in innate immunity, producing reactive oxygen species and reducing the severity and duration of parasitic infection and autoimmune disease. NCF1 also has a role in T cell activation.
