基因名：
MAN1B1
产品别名：
ERMAN1； ERManI； MANA-ER； MRT15； MAN1B1； mannosidase alpha class 1B member 1； mannosidase alpha class 1B member 1； endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase； ER alpha 1,2-mannosidase； Man9GlcNAc2-specific processing alpha-mannosidase； endoplasmic Reticulum Class I alpha-mannosidase； endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1； 内质网α-甘露糖苷酶1；
背景信息：
Endoplasmic Reticulum Mannosyl-Oligosaccharide 1,2-α-Mannosidase (MAN1B1) belongs to the glycosyl hydrolase 47 family. MAB1B1 is a single-pass type II membrane protein and widely expressed in many tissues. MAB1B1 is involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. MAB1B1 can be inhibited by both 1-deoxymannojirimycin (dMNJ) and kifunensine. Defects in MAN1B1 are the cause of mental retardation autosomal recessive type 15 (MRT15). Mental retardation is characterized by significantly below average general intellectual functioning, it is also associated with impairments in adaptative behavior and manifested during the developmental period.
