基因名：
SUPT16H
产品别名：
CDC68； FACTP140； NEDDFAC； SPT16； SPT16/CDC68； SUPT16H； SPT16 homolog, facilitates chromatin remodeling subunit； SPT16 homolog, facilitates chromatin remodeling subunit； FACT complex subunit SPT16； FACT 140 kDa subunit； chromatin-specific transcription elongation factor 140 kDa subunit； facilitates chromatin remodeling 140 kDa subunit； facilitates chromatin transcription complex subunit SPT16； hSPT16； suppressor of Ty 16 homolog； 染色体特异性转录延伸因子；
背景信息：
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene.
