基因名：
ERLIN2
产品别名：
C8orf2； Erlin-2； NET32； SPFH2； SPG18； ERLIN2； ER lipid raft associated 2； ER lipid raft associated 2； erlin-2； SPFH domain family, member 2； endoplasmic reticulum lipid raft-associated protein 2； epididymis secretory sperm binding protein； spastic paraplegia 18 (autosomal dominant)； stomatin-prohibitin-flotillin-HflC/K domain-containing protein 2； 内质网脂质Raft关联蛋白2(ERLIN2)； 内质网脂质转运相关蛋白2；
背景信息：
SPFH2 is a ubiquitously expressed 339 amino acid protein that belongs to the band 7/mec-2 family. Localized to lipid raft-like domains in the membrane of the endoplasmic reticulum (ER), SPFH2 plays a crucial role in the ER-associated degradation (ERAD) pathway that removes metabolically regulated and aberrant proteins from the ER. Specifically, SPFH2 associates with IP3R-I (Inositol 1,4,5-triphosphate receptor I), a substrate of the ERAD pathway, and facilitates its polyubiquitination and subsequent degradation. Three isoforms of SPFH2 are expressed due to alternative splicing events.
