基因名:
ZWINT
产品别名:
HZwint-1; KNTC2AP; SIP30; ZWINT1; ZWINT; ZW10 interacting kinetochore protein; ZW10 interacting kinetochore protein; ZW10 interactor; SNAP25 interacting protein of 30 kDa; ZW10 interactor, kinetochore protein; human ZW10 interacting protein-1; zwint-1; ZW10交互子(ZWINT); 着丝粒ZW101;
背景信息:
ZW10 Interactor is localized to the kinetochores from late Prophase to Anaphase and has a uniform distribution in the cytoplasm of Interphase cells. ZWINT interacts ZW10, MIS12 and NDC80 subunit of the NDC80 complex specifically during mitosis. ZWINT is a part of the MIS12 complex which is required for kinetochore formation and spindle checkpoint activity. In addition, ZWINT is required to target ZW10 to the kinetochore at prometaphase.