基因名：
ADAMTS13
产品别名：
ADAM-TS13； ADAMTS-13； C9orf8； VWFCP； vWF-CP； ADAMTS13； ADAM metallopeptidase with thrombospondin type 1 motif 13； ADAM metallopeptidase with thrombospondin type 1 motif 13； A disintegrin and metalloproteinase with thrombospondin motifs 13； a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 13； vWF-cleaving protease； von Willebrand factor-cleaving protease； 整合素样金属蛋白酶与凝血酶13型； 血管性血友病因子裂解蛋白酶(vWFCP)；
背景信息：
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene is the von Willebrand Factor (vWF)-cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2008].
