基因名：
TOPBP1
产品别名：
Dpb11； TOP2BP1； TOPBP1； DNA topoisomerase II binding protein 1； DNA topoisomerase II binding protein 1； DNA topoisomerase 2-binding protein 1； DNA topoisomerase II-beta-binding protein 1； topoisomerase (DNA) II binding protein 1； DNA拓扑异构酶2结合蛋白1； 拓扑异构酶Ⅱ结合蛋白1(TOPBP1)；
背景信息：
Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR.
