基因名：
RAPGEF4
产品别名：
CAMP-GEFII； CGEF2； EPAC； EPAC 2； EPAC2； Nbla00496； RAPGEF4； Rap guanine nucleotide exchange factor 4； Rap guanine nucleotide exchange factor 4； rap guanine nucleotide exchange factor 4； RAP guanine-nucleotide-exchange factor (GEF) 4； Rap guanine nucleotide exchange factor (GEF) 4； cAMP-regulated guanine nucleotide exchange factor II； exchange factor directly activated by cAMP 2； exchange protein directly activated by cAMP 2； putative protein product of Nbla00496； 鸟嘌呤核苷酸交换因子4；
背景信息：
3',5' cyclic adenosine monophosphate (cAMP)-regulated guanine nucleotide exchange factors Epac1 (cAMP-GEFI) and Epac2 (cAMP-GEFII) activate the ras family GTPases Rap1 and Rap2 by promoting GTP binding in a cAMP-dependent manner (1,2). Eukaryotic cAMP is a second messenger that induces physiological responses such as gene expression, growth, differentiation, secretion and neurotransmission (3). Human EPAC2 contains at least 31 exons and maps to chromosome 2q31 (4). The 4.4-kb Epac2 transcript is prominent in brain and adrenal gland (5,6). Within the brain, expression is strong in cortex, occipital pole, frontal lobe, temporal lobe, amygdala, putamen, hippocampus and cerebellum (5,6).
