基因名：
SLC27A5
产品别名：
ACSB； ACSVL6； BACS； BAL； FACVL3； FATP-5； FATP5； VLACSR； VLCS-H2； VLCSH2； SLC27A5； solute carrier family 27 member 5； solute carrier family 27 member 5； bile acyl-CoA synthetase； BA-CoA ligase； VLACS-related； bile acid-CoA ligase； cholate--CoA ligase； fatty acid transport protein 5； fatty-acid-Coenzyme A ligase, very long-chain 3； solute carrier family 27 (fatty acid transporter), member 5； very long-chain acyl-CoA synthetase homolog 2； very long-chain acyl-CoA synthetase-related protein； 脂肪酸转运蛋白5； 脂肪酸转运蛋白5(SLC27A5)；
背景信息：
SLC27A5 is an isozyme of very long chain acyl CoA synthetase (VLCS). It is an acyl CoA synthetase involved in bile acid metabolism and is proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. It seems to activate secondary bile acids entering the liver from the enterohepatic circulation. In vitro, it also activates 3 alpha,7 alpha,12 alpha trihydroxy 5 beta cholestanate (THCA), the C27 precursor of cholic acid derived from the de novo synthesis from cholesterol.
