基因名：
COPS5
产品别名：
CSN5； JAB1； MOV-34； SGN5； COPS5； COP9 signalosome subunit 5； COP9 signalosome subunit 5； COP9 signalosome complex subunit 5； 38 kDa Mov34 homolog； COP9 constitutive photomorphogenic homolog subunit 5； jun activation domain-binding protein 1； signalosome subunit 5； testis secretory sperm-binding protein Li 231m； Jun激活区域-连接蛋白1；
背景信息：
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.
