基因名：
GADD45G
产品别名：
CR6； DDIT2； GADD45gamma； GRP17； GADD45G； growth arrest and DNA damage inducible gamma； growth arrest and DNA damage inducible gamma； growth arrest and DNA damage-inducible protein GADD45 gamma； DDIT-2； DNA damage-inducible transcript 2 protein； GADD45-gamma； cytokine-responsive protein CR6； gadd-related protein, 17 kD； 生长停滞DNA损伤可诱导蛋白γ(GADD45g)；
背景信息：
Growth Arrest and DNA Damage-Inducible Protein GADD45 Υ (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. GADD45G is also involved in the regulation of growth and apoptosis. GADD45G inhibits cell growth and differentiation by androgens. The mRNA expression is down-regulated in hepatocellular carcinoma.
