基因名：
PPARGC1A
产品别名：
LEM6； PGC-1(alpha)； PGC-1alpha； PGC-1v； PGC1； PGC1A； PPARGC1； PPARGC1A； PPARG coactivator 1 alpha； PPARG coactivator 1 alpha； peroxisome proliferator-activated receptor gamma coactivator 1-alpha； L-PGC-1alpha； PGC-1-alpha； PPAR gamma coactivator variant form； PPARGC-1-alpha； PPARgamma coactivator 1alpha； ligand effect modulator-6； 过氧化物酶体增殖物激活受体γ辅激活因子1α(PPARgC1a)； 过氧化物酶体增殖物激活受体γ辅激活子1α； 过氧化物酶体增殖物激活受体γ辅激活子1α+β；
背景信息：
The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity (referenced from entrez gene.
