基因名：
SPINT2
产品别名：
DIAR3； HAI-2； HAI2； Kop； PB； SPINT2； serine peptidase inhibitor, Kunitz type 2； serine peptidase inhibitor, Kunitz type 2； kunitz-type protease inhibitor 2； HGF activator inhibitor 2； Kunitz domain containing protein overexpressed in pancreatic cancer； hepatocyte growth factor activator inhibitor type 2； hepatocyte growth factor activator inhibitor-2； serine protease inhibitor, Kunitz type, 2； testicular tissue protein Li 183； 丝氨酸肽酶抑制因子Kunitz型2(SPINT2)； 肝细胞生长因子激活抑制蛋白2；
背景信息：
Hepatocyte Growth Factor Activator Inhibitor Type 2 (HAI2) is a single-pass type I membrane protein and contains two BPTI/Kunitz inhibitor domains. The first Kunitz domain is mainly responsible for the inhibitory activity against hepatocyte growth factor activator (HGFA). HAI2 is expressed in placenta, kidney, pancreas, prostate, testis, thymus and trachea. HAI2 serves as a inhibitor of HGF activator. It also inhibits plasmin, plasma and tissue kallikrein and factor XIa. Defects in HAI2 are the cause of diarrhea type 3 (DIAR3), also known as congenital sodium diarrhea (CSD).
