基因名：
HTATIP2
产品别名：
CC3； SDR44U1； TIP30； HTATIP2； HIV-1 Tat interactive protein 2； HIV-1 Tat interactive protein 2； oxidoreductase HTATIP2； 30 kDa HIV-1 TAT-interacting protein； HIV-1 TAT-interactive protein 2； HIV-1 Tat interactive protein 2, 30kDa； Tat-interacting protein (30kD)； short chain dehydrogenase/reductase family 44U, member 1； TIP30蛋白；
背景信息：
Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Tissue specificity: Ubiquitous. Highest level in liver. High levels in lung, skeletal muscle, pancreas and placenta. Moderate levels in heart and kidney. Low levels in brain.
