基因名：
AGR2
产品别名：
AG-2； AG2； GOB-4； HAG-2； HEL-S-116； HPC8； PDIA17； XAG-2； AGR2； anterior gradient 2, protein disulphide isomerase family member； anterior gradient 2, protein disulphide isomerase family member； anterior gradient protein 2 homolog； anterior gradient homolog 2； epididymis secretory protein Li 116； protein disulfide isomerase family A, member 17； secreted cement gland homolog； secreted cement gland protein XAG-2 homolog； 前梯度同源蛋白2； 前梯度蛋白2(AGR2)；
背景信息：
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of EGF receptor. Mature human AGR2 is 155 amino acids (aa) in length (aa 21 - 175). Cys81 is presumed to participate in intermolecular bond formation. Over aa 21 - 175, human AGR2 shares 94% aa identity with mouse AGR2.
