基因名：
CARM1
产品别名：
PRMT4； CARM1； coactivator associated arginine methyltransferase 1； coactivator associated arginine methyltransferase 1； histone-arginine methyltransferase CARM1； protein arginine N-methyltransferase 4； 磷酸化蛋白精氨酸N甲基4； 蛋白精氨酸N甲基4；
背景信息：
Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' and activates transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C.
