基因名:
VAT1
产品别名:
VATI; VAT1; vesicle amine transport 1; vesicle amine transport 1; synaptic vesicle membrane protein VAT-1 homolog; membrane protein of cholinergic synaptic vesicles; vesicle amine transport protein 1 homolog (T. californica); 嗜铬颗粒胺转运蛋白VMAT1;
背景信息:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008].