基因名：
TAB1
产品别名：
3'-Tab1； MAP3K7IP1； TAB1； TGF-beta activated kinase 1 (MAP3K7) binding protein 1； TGF-beta activated kinase 1 (MAP3K7) binding protein 1； TGF-beta-activated kinase 1 and MAP3K7-binding protein 1； TAK1-binding protein 1； mitogen-activated protein kinase kinase kinase 7-interacting protein 1； transforming growth factor beta-activated kinase-binding protein 1； 丝裂原激活蛋白激酶激酶激酶7相互作用蛋白1(MAP3K7IP1)； 磷酸化转化生长因子β活化激酶结合蛋白1； 转化生长因子β活化激酶结合蛋白1；
背景信息：
TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta and members of the Toll IL 1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N terminus acts as a dominant negative inhibitor of TGF beta, demonstrating how this protein can function as a mediator between TGF beta receptors and TAK1.
