基因名：
PRMT5
产品别名：
HRMT1L5； HSL7； IBP72； JBP1； SKB1； SKB1Hs； PRMT5； protein arginine methyltransferase 5； protein arginine methyltransferase 5； protein arginine N-methyltransferase 5； 72 kDa ICln-binding protein； HMT1 hnRNP methyltransferase-like 5； SKB1 homolog； histone-arginine N-methyltransferase PRMT5； jak-binding protein 1； shk1 kinase-binding protein 1 homolog； 组蛋白精氨酸甲基转移酶5；
背景信息：
Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.
