基因名：
NDRG1
产品别名：
CAP43； CMT4D； DRG-1； DRG1； GC4； HMSNL； NDR1； NMSL； PROXY1； RIT42； RTP； TARG1； TDD5； NDRG1； N-myc downstream regulated 1； N-myc downstream regulated 1； protein NDRG1； N-myc downstream-regulated gene 1 protein； differentiation-related gene 1 protein； nickel-specific induction protein Cap43； protein regulated by oxygen-1； reducing agents and tunicamycin-responsive protein； 分化相关基因NDRG1； 磷酸化分化相关基因NDRG1；
背景信息：
Protein NDRG1 is a member of the N-Myc Downregulated Gene family, which is part of the α/β Hydrolase superfamily. Protein NDRG1 is a cytoplasmic protein that is involved in stress responses, hormone responses, cell growth and differentiation. Protein NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Protein NDRG1 mutuations are reported to be the cause for hereditary motor and sensory neuropathy-Lom. Decreased NDRG1 expression in glioma is linked to tumor progression; overexpression of NDRG1 is connected to malignant status of esophageal cancer.
