基因名：
NOD1
产品别名：
CARD4； CLR7.1； NLRC1； NOD1； nucleotide binding oligomerization domain containing 1； nucleotide binding oligomerization domain containing 1； nucleotide-binding oligomerization domain-containing protein 1； NLR family, CARD domain containing 1； caspase recruitment domain family, member 4； caspase recruitment domain-containing protein 4； nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1； 凋亡加强结构域蛋白4； 含核苷酸结合寡聚化域蛋白1(NOD1)；
背景信息：
Enhances caspase-9-mediated apoptosis. Induces NF-kappa-B activity via RIPK2 and IKK-gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS). Forms an intracellular sensing system along with ARHGEF2 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIPK2 dependent NF-kappa-B signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides but also in the activation of NF-kappa-B by Shigella effector proteins IpgB2 and OspB.
