基因名：
LILRB2
产品别名：
CD85D； ILT-4； ILT4； LIR-2； LIR2； MIR-10； MIR10； LILRB2； leukocyte immunoglobulin like receptor B2； leukocyte immunoglobulin like receptor B2； leukocyte immunoglobulin-like receptor subfamily B member 2； CD85 antigen-like family member D； Ig-like transcript 4； leucocyte Ig-like receptor B2； leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2； monocyte/macrophage immunoglobulin-like receptor 10； myeloid inhibitory receptor 10； 白细胞免疫球蛋白样受体亚家族B成员2(LILRB2)； 细胞表面免疫球蛋白样转录因子4；
背景信息：
Members of the immunoglobulin-like transcript (ILT) family are activating and inhibitory immunoreceptors whose genes are located same locus that encodes killer cell Ig-like receptors (KIR). Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 (LIR-2) is a type I transmembrane protein. LIR-2 is expressed primarily on monocytes and dendritic cells (DC). Human LIR-2 is produced as a 598 amino acino acid precursor including a 21 aa signal sequence, a 440 aa extracellular domain (ECD), a 21 aa transmenbrane segment, and a 116 aa cytoplasmic domain. LIR-2 binds to Classical MHCI proteins. Ligation of LIR-2 incluces Tyr phosphorylation within its cytoplasmic ITIMs, a requirement for association with SHP-1. LIR-2 mediates tolerogenic DC-induced CD4+ T cell energy in vitro and in vivo.
