基因名：
STAM2
产品别名：
Hbp； STAM2A； STAM2B； STAM2； signal transducing adaptor molecule 2； signal transducing adaptor molecule 2； signal transducing adapter molecule 2； HSE1 homolog； Hrs-binding protein； STAM-2； STAM-like protein containing SH3 and ITAM domains 2； signal transducing adaptor molecule (SH3 domain and ITAM motif) 2； 信号转导衔接分子2(STAM2)； 信号转导衔接蛋白1；
背景信息：
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
