基因名：
PSME3
产品别名：
HEL-S-283； Ki； PA28-gamma； PA28G； PA28gamma； REG-GAMMA； PSME3； proteasome activator subunit 3； proteasome activator subunit 3； proteasome activator complex subunit 3； 11S regulator complex gamma subunit； 11S regulator complex subunit gamma； Ki antigen； Ki nuclear autoantigen； REG gamma-3； activator of multicatalytic protease subunit 3； epididymis secretory protein Li 283； proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)； proteasome activator 28 subunit gamma； proteasome activator 28-gamma； 蛋白酶体激活因子PA28γ； 蛋白酶激活亚基3(PSME3)；
背景信息：
PA28 (also called the 11S regulatory complex) is another activator of the 20S proteasome, which assembles on either one or both ends of the 20S proteasome in an ATP-independent manner. PA28 can greatly enhance the peptidase activities of the 20S proteasome, but not for degradation of ubiquitinated proteins. The PA28 activator is a complex of two alternating homologous subunits, PA28α and PA28β, which assembles as a hexameric ring with an α3β3 stoichiometry. PA28α and PA28β are induced by interferon. Functionally, PA28 enhances the generation of class I peptides for antigen presentation. The third subunit, PA28γ, was recently identified in the nucleus. Recombinant PA28α and PA28β form a heptomeric ring; whereas PA28γ forms a hexameric ring. All of them can stimulate the peptidase activities of the 20S proteasome.
