基因名：
TNK2
产品别名：
ACK； ACK-1； ACK1； p21cdc42Hs； TNK2； tyrosine kinase non receptor 2； tyrosine kinase non receptor 2； activated CDC42 kinase 1； activated Cdc42-associated kinase 1； activated p21cdc42Hs kinase； tyrosine kinase non-receptor protein 2； 磷酸化Ack1； 醋酸激酶1； 非受体酪氨酸激酶2(TNK2)；
背景信息：
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq].
