基因名：
PDIA6
产品别名：
ERP5； P5； TXNDC7； PDIA6； protein disulfide isomerase family A member 6； protein disulfide isomerase family A member 6； protein disulfide-isomerase A6； ER protein 5； endoplasmic reticulum protein 5； epididymis secretory sperm binding protein； protein disulfide isomerase P5； protein disulfide isomerase-associated 6； protein disulfide isomerase-related protein； thioredoxin domain containing 7 (protein disulfide isomerase)； thioredoxin domain-containing protein 7； 蛋白二硫化物异构酶A6(PDIA6)； 蛋白二硫异构酶A6；
背景信息：
Protein Disulfide-Isomerase A6 (PDIA6) is a 48.5kDa protein that belongs to the protein disulfide isomerase family (PDI). PDIA6 is an enzyme in the endoplasmic reticulum in eukaryotes which catalyzes the formation and breakage of disulfide bonds between cysteine residues within proteins as they fold. The PDIA6 expressed in platelets, its functions as a chaperone that inhibits aggregation of misfolded proteins. PDIA6 is part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1. PDIA6 also plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin.
