基因名：
PQBP1
产品别名：
MRX2； MRX55； MRXS3； MRXS8； NPW38； RENS1； SHS； PQBP1； polyglutamine binding protein 1； polyglutamine binding protein 1； polyglutamine-binding protein 1； 38 kDa nuclear protein containing a WW domain； polyglutamine tract-binding protein 1； 多谷氨酰胺结合蛋白1；
背景信息：
Polyglutamine(Q) tract binding protein-1 (PQBP-1) is a transcription repressor that associates with polyglutamine tract-containing transcription regulators and causative genes for neurodegenerative disorders. Hepta- and di-amino acid repeat sequences rich in polar residues are essential for PQBP-1 to interact with polyglutamine tract-containing proteins (i.e. huntingtin, androgen receptor and Brain-2). PQBP-1 contains a WWP/WW domain that binds proline-rich motifs and a C2 domain that can influence Ca2+-dependent phospholipid signaling. PQBP-1 localizes to the nucleus and is present in neurons throughout the brain, with abundant levels in hippocampus, cerebellar cortex and olfactory bulb. The human PQBP-1 gene maps to chromosome Xp11.23.
