基因名：
PARP3
产品别名：
ADPRT3； ADPRTL2； ADPRTL3； ARTD3； IRT1； PADPRT-3； PARP3； poly(ADP-ribose) polymerase family member 3； poly(ADP-ribose) polymerase family member 3； protein mono-ADP-ribosyltransferase PARP3； ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2； ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3； ADP-ribosyltransferase diphtheria toxin-like 3； ADPRT-3； DNA ADP-ribosyltransferase PARP3； NAD(+) ADP-ribosyltransferase 3； NAD+ ADP-ribosyltransferase 3； poly [ADP-ribose] polymerase 3； poly(ADP-ribose) synthetase-3； poly[ADP-ribose] synthase 3； poly[ADP-ribose] synthetase 3； 蛋白质单ADP核糖基转移酶PARP3；
背景信息：
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.
Tissue specificity: Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
