重组酰基辅酶A硫酯酶8蛋白

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重组酰基辅酶A硫酯酶8蛋白

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Recombinant ACOT8
Recombinant acyl-CoA thioesterase 8 protein

基因名：

ACOT8

产品别名：

HNAACTE； NAP1； PTE-1； PTE-2； PTE1； PTE2； hACTE-III； hTE； ACOT8； acyl-CoA thioesterase 8； acyl-CoA thioesterase 8； acyl-coenzyme A thioesterase 8； HIV-Nef associated acyl-CoA thioesterase； Nef (lentivirus myristoylated factor) associated protein 1； choloyl-CoA hydrolase； choloyl-coenzyme A thioesterase； long-chain fatty-acyl-CoA hydrolase； palmitoyl-CoA hydrolase； peroxisomal acyl-CoA thioesterase 1； peroxisomal acyl-CoA thioesterase 2； peroxisomal acyl-coenzyme A thioester hydrolase 1； peroxisomal long-chain acyl-CoA thioesterase 1； thioesterase II； thioesterase III；酰基辅酶A硫酯酶8；

背景信息：

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Acyl-coenzyme A Thioesterase 8, also known as ACOT8 may mediate Nef-induced down-regulation of CD4. It is a major thioesterase in peroxisomes and competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). It shows a preference for medium-length fatty acyl-CoAs and may be involved in the metabolic regulation of peroxisome proliferation.