基因名：
PSMD6
产品别名：
Rpn7； S10； SGA-113M； p42A； p44S10； PSMD6； proteasome 26S subunit, non-ATPase 6； proteasome 26S subunit, non-ATPase 6； 26S proteasome non-ATPase regulatory subunit 6； breast cancer-associated protein SGA-113M； phosphonoformate immuno-associated protein 4； proteasome (prosome, macropain) 26S subunit, non-ATPase, 6； proteasome regulatory particle subunit p44S10； 蛋白酶调解因子6； 非ATP酶蛋白酶体26S亚基6(PSMD6)；
背景信息：
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. Proteasome 26S S10 is a non-ATPase subunit of the 19S regulator. It acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.
