基因名：
RNF40
产品别名：
BRE1B； RBP95； STARING； RNF40； ring finger protein 40； ring finger protein 40； E3 ubiquitin-protein ligase BRE1B； 95 kDa retinoblastoma protein binding protein； 95 kDa retinoblastoma-associated protein； BRE1 E3 ubiquitin ligase homolog B； BRE1-B； RING-type E3 ubiquitin transferase BRE1B； Rb-associated protein； ring finger protein 40, E3 ubiquitin protein ligase； 环指蛋白40；
背景信息：
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF40 (RING finger protein 40), also known as BRE1B, Staring or RBP95, is a 1,001 amino acid nuclear protein that contains one RING-type zinc finger. Expressed ubiquitously with highest expression in heart, testis and pancreas, RNF40 functions as an E3 ubiquitin-protein ligase that regulates the monoubiquitination and subsequent degradation of select residues on target proteins, such as Histone H2B and Syntaxin 1. In addition, RNF40 forms a ubiquitin ligase complex with UBCH6 (an E2 enzyme) and together, these proteins play a crucial role in regulation of the histone code. Four isoforms of RNF40 exist due to alternative splicing events.
