基因名：
NOS1AP
产品别名：
6330408P19Rik； CAPON； NPHS22； NOS1AP； nitric oxide synthase 1 adaptor protein； nitric oxide synthase 1 adaptor protein； carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein； C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)； C-terminal PDZ ligand of neuronal nitric oxide synthase protein； ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain； nitric oxide synthase 1 (neuronal) adaptor protein； 一氧化氮合酶1衔接蛋白(NOS1AP)； 神经型一氧化氮合成酶结合蛋白；
背景信息：
CAPON (carboxy-terminal PDZ ligand of nNOS) selectively binds within the 100 amino acid PDZ domain of the neuronal nitric oxide synthase (nNOS), but not to endothelial NOS or inducible NOS, and sequesters nNOS in the cytosol. Biosynthesis of the neurotransmitter nitric oxide (NO) requires the association of nNOS with various synaptic proteins, including syntrophin, postsynaptic density (PSD)95 and PSD93 through a scaffolding PDZ domain. These proteins facilitate the transport of nNOS to the plasma membrane, where it is catalytically activated by NMDA-receptor mediated calcium channels. The association of nNOS with PSD95 or PSD93 is regulated by CAPON. The carboxy terminus of CAPON binds to the PDZ domain, competes with PSD95 and PSD93 for binding to nNOS and in turn prevents the translocation and catalytic activation of nNOS.
