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重组组蛋白去甲基化酶JMJ2A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

重组赖氨酸特异性去甲基化酶4A(KDM4A)蛋白
Recombinant KDM4A
基因名:

KDM4A


产品别名:

JHDM3A; JMJD2; JMJD2A; TDRD14A; KDM4A; lysine demethylase 4A; lysine demethylase 4A; lysine-specific demethylase 4A; [histone H3]-trimethyl-L-lysine(36) demethylase 4A; [histone H3]-trimethyl-L-lysine(9) demethylase 4A; jmjC domain-containing histone demethylation protein 3A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; lysine (K)-specific demethylase 4A; tudor domain containing 14A; 组蛋白去甲基化酶JMJ2A; 赖氨酸特异性去甲基化酶4A(KDM4A);


背景信息:
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
 
 
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