基因名：
DZIP3
产品别名：
PPP1R66； UURF2； hRUL138； DZIP3； DAZ interacting zinc finger protein 3； DAZ interacting zinc finger protein 3； E3 ubiquitin-protein ligase DZIP3； DAZ interacting protein 3, zinc finger； DAZ-interacting protein 3； RING-type E3 ubiquitin transferase DZIP3； RNA-binding RING-H2 protein-ubiquitin ligase； RNA-binding ubiquitin ligase of 138 kDa； UURF2 ubiquitin ligase； human RNA-binding ubiquitin ligase of 138 kDa； protein phosphatase 1, regulatory subunit 66； zinc finger DAZ interacting protein 3； E3泛素蛋白连接酶dzip3； RNA结合泛素连接酶DZIP3；
背景信息：
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). DZIP3 (DAZ interacting protein 3, zinc finger), also known as UURF2 or hRUL138, is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events.
